Brief Reports
Associations Between Vitamin D and Self-Reported Respiratory Disease in Older People from a Nationally Representative Population Survey
Article first published online: 6 MAY 2013
DOI: 10.1111/jgs.12254
© 2013, Copyright the Author Journal compilation © 2013, The American Geriatrics Society
Additional Information(Show All)
Keywords:
- serum 25(OH)D concentrations;
- respiratory diseases;
- older people;
- England;
- nationally representative population survey
Objectives
To
investigate the association between serum 25-hydroxy vitamin D
(25(OH)D) concentrations and respiratory diseases in older people.
Design
Cross-sectional, nationally representative sample.
Setting
Community.
Participants
Two thousand seventy noninstitutionalized adults aged 65 and older taking part in the Health Survey for England 2005.
Measurements
Serum
25(OH)D levels, self-reported long-term respiratory tract diseases, and
covariates (age, sex, social class, season of examination, use of
vitamin supplements, and physical health status).
Results
Participants
with severe deficiency (25(OH)D < 35 nmol/L) had more than twice the
risk of respiratory disease than those in the highest quartile of
25(OH)D status (>64 nmol/L), and those with moderate deficiency
(second quartile: 25(OH)D 35–48.9 nmol/L) had 1.75 times greater odds of
respiratory diseases, even after adjustment with covariates. Adjusted
analysis showed that those in the third quartile (25(OH)D 49.0 to
63.9 nmol/L) also had a greater risk of respiratory disease (odds
ratio = 1.63, 95% confidence interval = 1.04–2.57).
Conclusion
Low
serum 25(OH)D concentrations are associated with respiratory disease.
Ensuring adequate 25(OH)D levels is of public health importance for
older populations living in northern latitudes and may be an effective
way to prevent concurrent respiratory infections and related
complications in older people. Further studies are required to
investigate whether vitamin D supplementation may reduce the incidence
and exacerbations of respiratory disease.
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