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MT2, Melanotan II (Afamelanotide)

Trade Names:	MT2, Melanotan
Chemical Names:	Afamelanotide
Routes:	Subcutaneous Injection

Melanotan II (MT2) was first synthesized at the University of Arizona in the 1980’s. Melanotan II is a peptide originally developed as a skin tanning agent, but subsequently investigated as a potential treatment for sexual dysfunction. 

To date there is no medically approved drug that contains the Melanotan II peptide, instead all available products are from commercial labs that are allowed to produce and distribute peptides as research products.

Even though the only Melanotan II peptides  available to the general public are unlicensed and unregulated drugs, thousands of people use it daily. A number of health and drug control agencies around the world issued warnings to the potential of health risks associated with unregulated medications.
Regardless of all the warnings the popularity of MT2 seems to be on the increase. One obvious reason for the popularity of MT2 is that it actually works and results are noticed fairly quickly. 
Another cause for the thriving trade of MT2 is that it’s not illegal to buy, import or use in most countries.

Since there’s no brand name  product available no official guideline has yet been established on the correct usage of this peptide. However through trial and error and experimentation the MT2 community developed a variety of protocols. The most popular and effective protocols are those that make use of a “loading” phase followed by a “maintenance” phase.

The loading phase is normally limited to about 3 to 5 days and in this time dosages of 0.5 to 1mg are injected subcutaneously nightly. Near the end of this phase one or two tanning sessions are taken so that the tanning process can be kick started. It’s very important to expose all parts of the body to equal amounts of sunlight or ultraviolet radiation. 

This is to allow for a uniform tan and to limit chances of dark or lighter spots. Results are rapid and care should be taken not to overdo usage  as that will result in an abnormally dark appearance.

The purpose of the maintenance phase is to prolong the period for which the tanned skin is required. Usually a dose of 0.5mg is taken 1-2 times per week. This might be altered depending on how the person reacts. If the tan is getting lighter the dosage might be increased or the period between injections shortened. If the tan is getting to dark the dosage can be lowered or the injection frequency decreased.


 
A number of initial side-effects can be expected when first using MT2, this is due to the structure of the molecule not entirely mimicking that of natural human a-MSH (alpha-melanocyte stimulating hormone) hormone.

 The body’s immune system will recognize it as being foreign and thus an allergic response may occur.

Facial flushing similar to initial Vitamin B3 Niacin non flushing formula. 
The melanotan flushing effects are less pronounced and usually transient within 30-45 minutes. Again prophylactic use of a small dose of benedryll  prior to using the peptide will eliminate or lower this initial side possible side effect.
Allerdryl/benedryl  can be  used as a preventive for those people who are especially sensitive to taking MT2.
Just as well, much lower concentrations of the injected drug would also lessen the side-effects.

 Some people find that taking the first few shots at night before bed lowers or reduces the initial flushing side effects.
Any transient nausea can be eliminated by ingesting a small amount of ginger, prior to using the peptide.

 The lyophilized powder may be stored at 4 C for several months . When you reconstitute to nominal volume and store at -20 C, the reconstituted product should be stable for 24 months. 
Best long-term storage solution is to store in lyophilized powder form at -20C. The reconstituted solution is best injected with an insulin syringe.

Use a 1 Ml insulin with a 31 gauge needle. 
Start with 0.5 Iu to 1.0 Iu on the scale of 10.

Reconstituting with 2.5 ml of sterile Na solution will allow for proper dosing.
5-10Iu on a regular 100Iu insulin syringe usually works best.

As with any herbal, peptide or medication always go slow to gauge individual sensitivity.

If you feel unwell, always seek medical attention, call the Telehealth 24/7 

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