Wednesday 24 May 2017

Fluorinated Opioid relieves pain without side effects

Volume 95 Issue 10 | p. 8 | News of The Week
Issue Date: March 6, 2017 | Web Date: March 3, 2017

An opioid minus major side effects

Fluorinated version of fentanyl is active only in areas of inflammation, eliminating troublesome effects in rats
When given to rats, a new opioid relieves their pain but doesn’t cause the negative side effects typically associated with this class of analgesic, such as addiction, respiratory depression, and constipation (Science 2017, DOI: 10.1126/science.aai8636). “These things are big problems when we treat patients for long periods of time with opioids,” says Christoph Stein, a professor of anesthesiology and critical care medicine at . . .


I will post the remained of this soon
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Semax for cognition and gastric ulcer

 https://www.ncbi.nlm.nih.gov/pubmed/15792140

Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(2):35-40.

[Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency].

[Article in Russian]
Gusev EI, Skvortsova VI, Chukanova EI.

Abstract

One hundred and eighty-seven patients with different stages of cerebrovascular insufficiency (CI) have been examined. A diagnosis of CI was based on the results of neurological and neuropsychological study, ultrasonic dopplerography, rheo- and encephalography, electrocardiography, brain MRI and eyegrounds examination. Neurological scales were used for neurological status assessment and further data processing. The study aimed at evaluation of tolerability and clinical efficacy of the medication and complications in CI course. Semax treatment resulted in significant clinical improvement, stabilization of the disease progress and reduced a risk of stroke and transitory ischemic attacks in the disease course. The drug is featured by minor percent of side-effects and is well tolerated by patients, including those of older age groups.
PMID:
15792140
[Indexed for MEDLINE]
Bull Exp Biol Med. 2002 Jul;134(1):73-4.

Therapy of peptic ulcer with semax peptide.

Ivanikov IO1, Brekhova ME, Samonina GE, Myasoedov NF, Ashmarin IP.

Author information

Abstract

Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers. On day 14 of treatment ulcer healing was observed in 89.5% patients receiving intranasal Semax (1% solution, 2-4 drops 3 times a day for 10 days) vs. 30.8% in the control group. Clinical studies of antiulcer activity of Semax in different combinations with usual antiulcer drugs are needed.
PMID:
12459874


What are the benefits of Semax?

Some purported benefits of Semax includes the following:
  • Increased memory capacity
  • Improved learning ability
  • Increased concentration, focus and perception
  • Increased energy and improved energy balance
  • Better moods
  • Improved immune functioning
  • Decrease mental strain from intellectually exhausting activities
  • Increase brain’s ability to adapt on chronic stress
  • Anxiety and depression treatment
  • Treatment of Attention Deficit Hyperactivity Disorder (ADHD)
  • Treatment for sleep disorders
  • Improve memory of elderly patient
  • Prevents symptoms of neurodegenerative disorders
  • TIA and stroke treatment
  • Optic nerve disorder treatment
  • Peptic ulcer disease (PUD) treatment
  • Protects the brain from damage

Is Semax safe to use?

Despite its strength, Semax is relatively safe for human use. There are no serious side effects associated with it. Accounts from users who took more than what was recommended revealed minimal side effects (e.g. headaches). It also has a low toxicity profile and has no risk for causing dependence or tolerance at that. Nonetheless, it is still critical to follow the recommended dosage range.

How should you take Semax?

Please note that Semax can only be administered via the subcutaneous administration and intranasal route. Semax should never be taken orally, sublingually or any route other than subcutaneously as it will be rendered inactive. The recommended daily dosage for Semax is 0.25 to 1 mg daily. For lyophilized Semax, remember to reconstitute it with Normal Saline  NaCl 0.09% before injection.

Always clean to sterile technique where possible

Intranasal administration for cognitive enhancement  has been a debated consideration for many years.
Trackable results  have , shall we say, varied considerably.should be limited to 2 to 3 drops on each nostril with 0.1% Semax solution taken twice a day. This will amount to exactly 50 mcg of active ingredient per Semax nasal spray. Due to its long half-life (about 12 to 24 hours), you may opt to limit Semax administration to once a day. It is also recommended that you cycle it every 14 days to achieve its maximal effects. Please note that the 1% Semax solution is meant for patients with severe medical problems including stroke. Semax should not be used continuously
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